SYMJEPI is used to treat severe, potentially life-threatening allergic reactions, or anaphylaxis. It delivers the same medicine as in the epinephrine auto-injectors (EAIs) you may be used to but in a small, portable, and easy-to-use device.
While SYMJEPI and EAIs are both used to treat severe allergic reactions, the devices used to give an injection are different. The SYMJEPI device is a single-dose, disposable, pre-filled syringe, unlike the spring-loaded syringe of an auto-injector. Because of this design, which allows the user to control the injection, there is no need to thrust the device into the thigh as is required with an EAI, which may reduce the risk of an injection-related injury. Furthermore, the SYMJEPI device is smaller and easier to carry with you, has a thinner needle than those in the most widely used EAIs, and features a safety guard to keep users protected after an injection has been given.
Common symptoms of anaphylaxis include severe itching, trouble breathing, wheezing, swelling of the lips and mouth, hives, and dizziness or fainting. However, the reaction affects everyone differently, so it's a good idea to be aware of all the different symptoms of an anaphylactic reaction. Be sure to check out the Anaphylaxis Overview section to learn more.
SYMJEPI should ONLY be injected into the middle of the outer thigh. Do not inject into your vein, buttocks, fingers, toes, hands, or feet. If an accident happens and you inject SYMJEPI into another part of your body, please seek medical treatment immediately.
Yes, SYMJEPI was designed to work effectively even when injected through clothing.
While 1 SYMJEPI device contains a full dose of epinephrine, it may be necessary to use the second device if the symptoms continue or recur. Seek immediate medical attention after using SYMJEPI and be sure to tell them that you have received an epinephrine injection.
SYMJEPI was designed to be easy to carry with you. It can fit in your pocket or purse when you're on the go, so you're never far from it should an allergic reaction happen. You are also encouraged to keep a SYMJEPI device wherever you or your child spends the most time, such as at school, work, and home.
While SYMJEPI is designed to be carried with you, the epinephrine in SYMJEPI is light sensitive and should be stored between 68°F and 77°F (20°C and 25°C).
Because an anaphylactic reaction can occur within minutes of exposure to an allergen, it's critical to carry your SYMJEPI with you at all times. To make this easier, you'll receive 2 SYMJEPI devices in a convenient carrying case with each prescription. This case can be separated if needed, but carry both devices with you in the event that the first dose does not fully relieve your symptoms.
The epinephrine in your SYMJEPI devices has an expiration date. Be sure to replace your SYMJEPI before this date, which can be found on the back of the carrying case, on the back of the device itself, and on the outer box.
Download the SYMJEPI app to keep track of your devices and receive refill alerts.
No, SYMJEPI cannot be reused. Some medicine may be left in the device but the correct dose has been injected if the plunger has been pushed all the way down and the window is at least partially blocked. The second device in your pack is there in case the first dose does not work fully on the reaction. Seek immediate medical attention after using SYMJEPI to make sure you are safe.
Take all used or expired SYMJEPI devices to your doctor or a hospital for proper disposal. Do NOT throw SYMJEPI in the garbage.
The epinephrine inside SYMJEPI should be clear and colorless. If you see that it is discolored (pinkish or brown), cloudy, or contains particles, you should bring it to your doctor immediately and replace the SYMJEPI device.
You have the option to get a new SYMJEPI prescription delivered through a pharmacy called PillPack. To check your price and then place an order, you'll start by creating an account and providing your insurance, if you’re using it. PillPack will show you the cost of SYMJEPI through your insurance, along with the cash price, before you complete your order. Delivery is free, so you'll only pay your co-pays or the best out-of-pocket price.
Once you’ve completed your order, PillPack will reach out to your doctor for a prescription. Then they'll keep you updated via email or text until your SYMJEPI arrives at your door.
For more information, and to begin the sign-up process, click here.
No, you do not need an existing prescription. PillPack will reach out to your doctor(s) to request a prescription. If your doctor feels SYMJEPI is a good fit for you based on your health history and previous experience with epinephrine medications, they will write a new prescription and send it straight to the pharmacy.
IMPORTANT NOTE: The health information contained above is provided for general educational purposes only. Please consult with your healthcare professional if you have any questions about your allergies or SYMJEPI.
SYMJEPI is indicated in the emergency treatment of allergic reactions (Type 1) including anaphylaxis to stinging insects (e.g., order Hymenoptera, which include bees, wasps, hornets, yellow jackets and fire ants) and biting insects (e.g., triatoma, mosquitoes), allergen immunotherapy, foods, drugs, diagnostic testing substances (e.g., radiocontrast media) and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis.
Warnings and Precautions
SYMJEPI may cause serious side effects.
Common side effects of SYMJEPI include:
These side effects may go away with rest. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SYMJEPI. For more information, ask your healthcare provider or pharmacist.
Please see full Prescribing Information for SYMJEPI.
To report SUSPECTED ADVERSE REACTIONS, contact Adamis Pharmaceuticals Corporation at
Warnings and Precautions